Borderlands 2 Natural Selection Annex Complete Mission And Location Guide
The Natural Selection Annex in Borderlands 2 serves as a premier arena for players looking to test their combat skills against hordes of dangerous Pandoran wildlife. Originally released as the Creature Slaughter Dome DLC, this location offers unique rewards, valuable experience, and an optimal fast-travel spawn point for endgame farming. Navigating to this hidden facility requires understanding its placement within the larger map of Pandora.
Finding the Entrance in the Wildlife Exploitation Preserve
To reach the Natural Selection Annex, players must first travel to the Wildlife Exploitation Preserve during or after the main story mission. Progress halfway through the preserve until reaching the central facility area near the vending machines. The doorway leading to the arena is located right next to these vendors, making it easy to miss if you rush past.
Entering the facility for the first time registers the zone in your game session. This transition allows Vault Hunters to use the annex transition door as a convenient spawn point when save-farming nearby loot midgets or legendary drops.
Overcoming the Creature Slaughter Arena Rounds
Inside the annex, players can accept the Creature Slaughter questline consisting of five increasingly difficult waves. Each round forces combatants to fight off swarms of Skags, Spiderants, Varkids, and Stalkers within a enclosed combat dome. Proper elemental weapons, particularly fire and corrosive gear, are critical for managing these aggressive beasts effectively.
Completing all five rounds unlocks exclusive rewards, including powerful weapons like Miss Moxxi's Creamer rocket launcher. Players should note that once all five rounds are completed and turned in, the quest cannot be replayed on that difficulty setting.
Tactical Benefits and Hidden Secrets
Beyond the main arena challenges, the Natural Selection Annex holds valuable secrets for dedicated completionists. Inside the shipping containers positioned near the arena floor, players can locate a hidden Cult of the Vault symbol painted on the ceiling. Interacting with this symbol awards Badass Rank and contributes toward total challenge completion.
Additionally, utilizing this zone as a reload hub significantly cuts down travel time when farming rare enemies in the preserve. Whether you are hunting for rare class mods or seeking high-octane combat, mastering this area is essential for any experienced player.